• Clinical Practice and Guidance Center

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  • Enhanced Methodology Adopted for Updates to the Guidelines

    The enhanced methodology incorporates the highest scientific standards for reviewing evidence-based literature, thus ensuring the most rigorous, reproducible, and transparent occupational health guidelines available. Under the new methodology, only evidence with the highest available rating (e.g., randomized controlled trials) is selected for critical appraisal. Each article that meets the inclusion criteria is reviewed, critically appraised, and abstracted into evidence tables that include details of study methods, outcomes, and statistical analyses. Panels of experts review the articles and evidence tables and agree on the strength-of-the-evidence ratings (A, B, C, or I). Panels then draft recommendations with citation of references for each recommendation. “First principles”, health benefits, side effects, and risks are explicitly considered and discussed in formulating recommendations. Recommendations are made under the following categories: strongly recommended (A), moderately recommended (B), recommended (C), insufficient-recommended (I), insufficient-no recommendation (I), insufficient not-recommended (I), recommended against (C), moderately recommended against (B), strongly recommended against (A).